LymphedemaV1, Main, Exploration, bibRecord, 000E09

Mechanosensitive β-catenin signaling regulates lymphatic vascular development

Identifieur interne : 000E09 ( Main/Exploration ); précédent : 000E08; suivant : 000E10

Mechanosensitive β-catenin signaling regulates lymphatic vascular development

Auteurs : Boksik Cha ; R. Sathish Srinivasan [États-Unis]

Source :

BMB Reports [ 1976-6696 ] ; 2016.

RBID : PMC:5070726

Descripteurs français

KwdFr :
- Animaux, Cellules endothéliales (métabolisme), Humains, Lymphangiogenèse, Modèles biologiques, Mécanotransduction cellulaire, Système lymphatique (métabolisme), Voie de signalisation Wnt, bêta-Caténine (métabolisme).
MESH :
- métabolisme : Cellules endothéliales, Système lymphatique, bêta-Caténine.
- Animaux, Humains, Lymphangiogenèse, Modèles biologiques, Mécanotransduction cellulaire, Voie de signalisation Wnt.

English descriptors

KwdEn :
- Animals, Endothelial Cells (metabolism), Humans, Lymphangiogenesis, Lymphatic System (metabolism), Mechanotransduction, Cellular, Models, Biological, Wnt Signaling Pathway, beta Catenin (metabolism).
MESH :
- chemical , metabolism : beta Catenin.
- metabolism : Endothelial Cells, Lymphatic System.
- Animals, Humans, Lymphangiogenesis, Mechanotransduction, Cellular, Models, Biological, Wnt Signaling Pathway.

Abstract

The Wnt/β-catenin signaling is an evolutionarily conserved pathway that plays a pivotal role in embryonic development and adult homeostasis. However, we have limited information about the involvement of Wnt/β-catenin signaling in the lymphatic vascular system that regulates fluid homeostasis by absorbing interstitial fluid and returning it to blood circulation. In this recent publication we report that canonical Wnt/β-catenin signaling is highly active and critical for the formation of lymphovenus valves (LVVs) and lymphatic valves (LVs). β-catenin directly associates with the regulatory elements of the lymphedema-associated transcription factor, FOXC2 and activates its expression in an oscillatory shear stress (OSS)-dependent manner. The phenotype of β-catenin null embryos was rescued by FOXC2 overexpression. These results suggest that Wnt/β-catenin signaling is a mechanotransducer that links fluid force with lymphatic vascular development. [BMB Reports 2016; 49(8): 403-404]

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5070726

DOI: 10.5483/BMBRep.2016.49.8.112
PubMed: 27418286
PubMed Central: 5070726

Affiliations:

États-Unis

Le document en format XML

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<front><div type="abstract" xml:lang="en"><p>The Wnt/β-catenin signaling is an evolutionarily conserved pathway that plays a pivotal role in embryonic development and adult homeostasis. However, we have limited information about the involvement of Wnt/β-catenin signaling in the lymphatic vascular system that regulates fluid homeostasis by absorbing interstitial fluid and returning it to blood circulation. In this recent publication we report that canonical Wnt/β-catenin signaling is highly active and critical for the formation of lymphovenus valves (LVVs) and lymphatic valves (LVs). β-catenin directly associates with the regulatory elements of the lymphedema-associated transcription factor, FOXC2 and activates its expression in an oscillatory shear stress (OSS)-dependent manner. The phenotype of β-catenin null embryos was rescued by FOXC2 overexpression. These results suggest that Wnt/β-catenin signaling is a mechanotransducer that links fluid force with lymphatic vascular development. [BMB Reports 2016; 49(8): 403-404]</p>
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Serveur d'exploration sur le lymphœdème

Mechanosensitive β-catenin signaling regulates lymphatic vascular development

Mechanosensitive β-catenin signaling regulates lymphatic vascular development

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	Serveur d'exploration sur le lymphœdème
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